Product Overview
Advanced Renal Technologies
provides an advanced dialysis fluid (dialysate) formulation
containing citric acid--the first major change in dialysate
chemical composition in 30 years.
Citrasate®
and DRYalysate®
Citrate dialysate is
available in two forms, Citrasate® liquid A concentrate
and DRYalysate® , a dry powdered version that
can be mixed by the user to make A concentrate. The use
of citric acid in the dialysate has been shown to be a safe
and effective way to provide better dialysis therapy.
Product Benefits
Citrate dialysis has
been shown to provide improved treatment for patients on
routine long-term hemodialysis when compared to currently
used dialysate formulations. Patients who appear to particularly
benefit from citrate dialysate are those with dialyzer clotting
or increased risk of bleeding problems. Patients in these
two categories include:
- those whose dialyzers clot despite
large amounts of heparin,
- those who cannot use heparin,
e.g., those with heparin antibodies, and
- patients actively bleeding or
who are at risk of hemorrhage.
Citrate dialysate is
safe and effective in all dialysis patients, but it has
been particularly effective because it improves dialyzer
reuse:
- Increases the dose of dialysis
- Corrects acidosis
- Improves dialysis in patients
who are "dialyzer clotters"
- Enables heparin-free dialysis
of patients with antibodies to heparin (HIT) or those
who are allergic to heparin
- Enables heparin-free dialysis
of patients with acute renal failure who are at risk of
bleeding
Back
to top
Product Information and Usage
Citrasate®
and DRYalysate® are available in all standard formulations.
Three concentrations (35X, 36.83X, and 45X) are supplied.
- Citrasate® liquid A concentrate
is available in individual-dose gallon jugs packaged four
per case, and it is also available in 50- and 55-gallon
barrels.
- DRYalysate® comes in powder
form that can be mixed on-site as needed. Its advantage
is lower shipping and storage costs, since DRYalysate®
occupies approximately 70% less space than liquid A concentrate.
DRYalysate® is packaged in convenient boxes that make
50 liters of A concentrate.
There is no
change in treatment routine or equipment required to use
Citrasate® or DRYalysate®. Switching
to citric acid dialysate is simple; just pour the citrate
A concentrate (Citrasate® or reconstituted DRYalysate®)
into the container normally used on your dialysis system,
or use it in the dialysis clinic's central supply system.
No alterations in the dialysis machine are necessary. Patients
and staff will see no difference in treatment procedures.
To them, the conversion is "transparent" and convenient.
There is no staff training needed before converting to either
of ART's citrate dialysate products. No special blood tests
are needed when doing citrate dialysis.
View the PDF
of the Citrasate
MSDS.
Back
to top
Citric Acid
Citric acid is a physiological
acid that is rapidly metabolized. It has a long and safe
history of use in medicine, most notably as an anticoagulant
used in the collection and storage of blood for transfusion.
Citric acid anticoagulates through the chemical binding
of calcium. Citrate dialysate contains only a small fraction
of the citric acid concentration used to anticoagulate blood,
yet evidence shows it has mild anticoagulation properties
that improve dialysis treatment.
Additional descriptions
of results obtained with citric acid dialysate can be found
in the section for Dialysis
Professionals.
Back
to top
|
